ΒΙΟΧΗΜΙΚΟ ΤΜΗΜΑ

Α. ΕΠΙΣΤΗΜΟΝΙΚΟ ΔΥΝΑΜΙΚΟ

ΠΡΟΙΣΤΑΜΕΝΟΣ:  Δρ. ΚΩΝΣΤΑΝΤΙΝΟΣ ΜΑΚΡΗΣ – ΒΙΟΛΟΓΟΣ Ph.D EurSpLM, FAACC

• Email: kostas.makris@kat-hosp.gr
• Τηλ: 213-2086038

ΝΙΚΟΛΑΟΣ ΕΥΘΥΜΙΟΠΟΥΛΟΣ – ΒΙΟΛΟΓΟΣ  MSc

ΑΘΗΝΑ ΠΑΣΑΝΙΚΟΛΑΚΗ – ΒΙΟΛΟΓΟΣ-ΧΗΜΙΚΟΣ MSc

ΙΟΥΛΙΑ ΤΡΥΦΩΝΙΔΗ – ΒΙΟΛΟΓΟΣ MSc

ΜΑΡΙΑ ΣΕΦΕΡΙΑΔΟΥ – ΧΗΜΙΚΟΣ MSc (ΕΠΙΚΟΥΡΙΚΗ)

Β. ΤΕΧΝΟΛΟΓΙΚΟ ΠΡΟΣΩΠΙΚΟ

ΕΛΕΝΗ ΔΗΜΗΤΡΑΝΤΖΟΥ – ΤΕ

ΕΥΤΥΧΊΑ ΚΟΤΡΩΤΣΙΟΥ – ΔΕ

ΒΑΣΙΛΕΙΟΣ ΣΚΙΑΔΑΣ – ΤΕ

ΚΑΛΟΒΥΡΝΑ ΠΑΝΑΓΙΩΤΑ-ANNA – ΤΕ – MSc

ΡΕΦΕΝΕ ΕΙΡΗΝΗ – ΤΕ – MSc

ΜΙΧΑΗΛΙΚΟΥ ΑΠΟΣΤΟΛΙΑ – ΔΕ

ΜΥΡΙΟΥΝΗ ΕΛΕΝΑ – ΤΕ (ΕΠΙΚΟΥΡΙΚΗ)

Στοιχεία Επικοινωνίας

Τηλέφωνο  Εργαστηρίου: 213-2086441,

Εργαστήριο Οστικού Μεταβολισμού: 213-2086701

e-mail Εργαστηρίου: biochemistry@kat-hosp.gr

ΤΟ ΠΡΟΣΦΕΡΟΜΕΝΟ ΚΛΙΝΙΚΟ-ΕΡΓΑΣΤΗΡΙΑΚΟ ΕΡΓΟ

Το Βιοχημικό Τμήμα του ΓΝΑ ΚΑΤ ιδρύθηκε το 1971 και από τη σύσταση του ΕΣΥ το 1982 ως σήμερα παραμένει ένα επιστημονικά αυτοτελές Τμήμα του Εργαστηριακού Τομέα του Νοσοκομείου.

Παρέχει καθημερινά τεράστιο όγκο αποτελεσμάτων εργαστηριακών εξετάσεων καθοριστικών για την διάγνωση, πρόγνωση, και θεραπεία των ασθενών που νοσηλεύονται στις Κλινικές, στις Μονάδες Εντατικής Θεραπείας (ΜΕΘ) και στα Εξωτερικά Ιατρεία του Νοσοκομείου. Το Εργαστήριό μας δέχεται και εξυπηρετεί γειτονικά Νοσηλευτικά Ιδρύματα με ειδικές εξετάσεις που εκτελούνται στο Εργαστήριο μας

Σήμερα στο Βιοχημικό Τμήμα λειτουργούν 2 σύγχρονοι μεικτοί αυτόματοι Βιοχημικοί/Ανοσοχημικοί Αναλυτές στους οποίους προσδιορίζονται περίπου 1.800.000 εξετάσεις κατ’ έτος που αφορούν όλο το φάσμα της Κλινικής Βιοχημείας

Επι πλέον κάθε χρόνο γίνονται επιπλέον περίπου 8.000-10.000 ειδικές εξετάσεις που αφορούν τις εξετάσεις των βιοχημικών δεικτών του οστικού μεταβολισμού. Για την εκτέλεση αυτών των εξετάσεων στο τμήμα βρίσκεται ενας σύγχρονος ανολογικός αναλυτής

Επιπλέον στο τμήμα λειτουργούν ένας σύγχρονος αναλυτής oύρων και ένας αναλυτής υγρής χρωματογραφίας υψηλής απόδοσης (HPLC) για την μέτρηση της γλυκιωμένης αιμοσφαιρίνης (HbA1c).

ΤΟ ΑΝΘΡΩΠΙΝΟ ΔΥΝΑΜΙΚΟ

Η στελέχωση του Βιοχημικού Τμήματος είναι άριστη συνδυάζοντας έμπειρο Επιστημονικό προσωπικό με διδακτορικούς και μεταπτυχιακούς τίτλους σπουδών, καθώς και πολυετή εμπειρία, συνέπεια, ευαισθησία και επιστημονική ενημέρωση, παραμένοντας απόλυτα εναρμονισμένο με τις σύγχρονες ανάγκες ενός Εργαστηρίου Κλινικής Χημείας-Κλινικής Βιοχημείας. Το Τεχνολογικό προσωπικό είναι επίσης έμπειρο και ενημερωμένο.

Διαρκής στόχος του Βιοχημικού Τμήματος παραμένει η υψηλή ποιότητα των διαγνωστικών εξετάσεων και η άμεση έκδοση των αποτελεσμάτων προς όφελος των ασθενών. Αυτό επιτυγχάνεται με τον αυστηρό καθημερινό εσωτερικό έλεγχο ποιότητας όλων των εξετάσεων που διενεργούνται στο Τμήμα και με τη συμμετοχή του τμήματος σε διεθνείς τακτικούς διεργαστηριακούς ελέγχους της ποιότητας (EQAS BIORAD, DEQAS, IFCC, ΕΣΕΑΠ) καθόλη τη διάρκεια του χρόνου καθιστώντας τα αποτελέσματα του εργαστηρίου έγκυρα και αξιόπιστα διεθνώς.

ΕΚΠΑΙΔΕΥΣΗ

Στο Βιοχημικό Τμήμα παρέχεται επίσης πλήρης εκπαίδευση σε ειδικευόμενους Ιατρούς στην ειδικότητα της Ιατρικής Βιοπαθολογίας-Εργαστηριακής Ιατρικής (12 μήνες).

Επιπλέον Επιστήμονες (Χημικοί, Βιοχημικοί, Βιολόγοι) και Τεχνολόγοι Ιατρικών Εργαστηρίων εκπαιδεύονται στα πλαίσια της πρακτικής τους άσκησης στο αντικείμενο της Κλινικής Χημείας- Κλινικής Βιοχημείας.

Σε μεταπτυχιακό επίπεδο το Βιοχημικό Τμήμα συμμετέχει στο μεταπτυχιακό πρόγραμμα σπουδών του ΕΚΠΑ «Μεταβολικά νοσήματα των οστών» με διαλέξεις και εκπόνηση διπλωματικών εργασιών

ΤΟ ΕΡΕΥΝΗΤΙΚΟ ΕΡΓΟ

Το επιστημονικό δυναμικό του Βιοχημικού τμήματος έχει αναπτύξει πλούσια επιστημονική δραστηριότητα η οποία μεταφράζεται σε

1. Περισσότερες από 80 δημοσιεύσεις σε διεθνή περιοδικά και 5 κεφάλαια σε ελληνικά και ξένα βιβλία τα οποία έχουν πάνω από 3.400 αναφορές (citations)
2. Πάνω από 100 παρουσίασεις και ομιλίες σε Διεθνή και Ελληνικά συνέδρια και αρκετές βραβεύσεις πρωτότυπων ερευνητικών εργασιών
3. Υποστήριξη και εκπόνηση στο τμήμα τουλάχιστον 10 διδακτορικών διατριβών
4. Συμμετοχή του επιστημπνικού δυναμικού σε διεθενείς επιστημονικές εταιρείες (IFCC, EFLM, AACC)

ΟΙ ΕΞΕΤΑΣΕΙΣ ΠΟΥ ΔΙΕΝΕΡΓΟΥΝΤΑΙ ΣΤΟ ΤΜΗΜΑ

Οι αναλύσεις που διενεργούνται στο Βιοχημικό Τμήμα καλύπτουν όλο το φάσμα εξετάσεων της Κλασσικής Κλινικής Χημείας-Κλινικής Βιοχημείας. Επιπλέον διενεργούνται ειδικές εξετάσεις προσδιορισμού

1.βιοχημικών δεικτών οστικού μεταβολισμού,

2. πρωτεϊνών νεφρικής και καρδιακής λειτουργίας,
3. ειδικών πρωτεϊνών λοίμωξης, φλεγμονής και σήψης,
4. μέτρηση επιπέδων φαρμάκων,
5. δεικτών νεοπλασίας,
6. δεικτών εγκεφαλικής βλάβης,
7. έλεγχο διαβήτη,

ΕΡΓΑΣΤΗΡΙΟ ΚΛΑΣΣΙΚΗΣ ΒΙΟΧΗΜΕΙΑΣ – ΑΝΟΣΟΧΗΜΕΙΑΣ

1α. Εξετασεις αίματος

(*) Υπό ανάπτυξη σύντομα

1β. Βιοχημικές εξετάσεις ούρων (24ωρες συλλογές)

(*) Υπό ανάπτυξη σύντομα

1γ. Εξετάσεις ούρων (τυχαίο δείγμα/πρώτα πρωϊνά – υπολογιστικές

(*) Υπό ανάπτυξη σύντομα

1δ. Μέτρηση Δεικτών Νεοπλασίας

1ε. Μέτρηση Επιπέδων Φρμάκων

1στ. Ελεγχος Θυρεοειδούς

1ζ. Ειδικές πρωτεΐνες – Έλεγχος Σήψης –Έλεγχος Νεφρικής λειτουργίας

(*) Υπό ανάπτυξη σύντομα

1η. Έλεγχος Διαβήτη – Δυναμικές δομικασίες

1θ. Έλεγχος Δεικτών Καρδιακής λειτουργίας

1ι. Έλεγχος Δεικτών Αναιμίας

1κ. Έλεγχος Δεικτών Εγκεφαλικής βλάβης

(*) Υπό ανάπτυξη σύντομα

2. ΕΡΓΑΣΤΗΡΙΟ ΕΛΕΓΧΟΥ ΔΕΙΚΤΩΝ ΟΣΤΙΚΟΥ ΜΕΤΑΒΟΛΙΣΜΟΥ – ΟΡΜΟΝΩΝ

2α. Οστικοί δείκτες

(*) Υπό ανάπτυξη σύντομα

2β. Ορμόνες

Οι εξετάσεις αυτές αφορούν τα κάτωθι βιολογικά υλικά

1. Αίμα (ορός)
2. Αίμα (πλάσμα)
3. Ολικό αίμα
4. Δυναμικές δοκιμασίες αίματος
5. Ούρα (τυχαίο δείγμα)
6. Ούρα (πρώτα πρωϊνά)
7. Ούρα (24-ωρη συλλογή)
8. Ούρα συλλογές ορισμένου χρόνου (4-ωρες, 8-ωρες)
9. Ούρα (διώρου/δεύτερα πρωϊνά)
10. Κόπρανα
11. Εγκεφαλονωτιαίο Υγρό (ΕΝΥ)
12. Αρθρικό Υγρό
13. Περιτοναϊκό Υγρό
14. Ασκιτικό Υγρό
15. Πλευριτικό Υγρό
16. Υγρό παροχέτευσης
17. Διϊδρώματα / εξιδρώματα (πάνελ εξετάσεων για την διάκριση διιδρωμάτων εξιδρωμάτων)
18. Οσφυϊκό

ΕΠΙΣΤΗΜΟΝΙΚΕΣ ΔΗΜΟΣΙΕΥΣΕΙΣ

1. Improving the Bias of Comparator Methods in Analytical Performance Assessments Through Recalibration. Pleus S, Eichenlaub M, Gerber T, Eriksson Boija E, Makris K, Haug C, Freckmann G. J Diabetes Sci Technol. 2022 Oct 22:19322968221133107. doi: 10.1177/19322968221133107. Online ahead of print
2. 25-OH Vitamin D concentrations measured by LC-MS/MS are equivalent in serum and EDTA plasma. van der Vorm LN, Le Goff C, Peeters S, Makris K, Cavalier E, Heijboer AC. Steroids. 2022 Nov;187:109096. doi: 10.1016/j.steroids.2022.109096. Epub 2022 Aug

3. Serum biomarkers for the assessment of muscle damage in various surgical approaches in primary total hip arthroplasty: a systematic review of comparative studies. Sarantis MG, Mandrekas PI, Stasi S, Makris K, Macheras GA, Mavrogenis AF, Babis GC, Nikolaou VS.Int Orthop. 2022 Aug;46(8):1681-1692. doi: 10.1007/s00264-022-05442-w

4. The effect of different consensus definitions on diagnosing acute kidney injury events and their association with in-hospital mortality. Nateghi Haredasht F, Antonatou M, Cavalier E, Delanaye P, Pottel H, Makris K. J Nephrol. 2022 Nov;35(8):2087-2095. doi: 10.1007/s40620-022-01323-
5. Effect of Calcium and Vitamin D Supplementation With and Without Collagen Peptides on Volumetric and Areal Bone Mineral Density, Bone Geometry and Bone Turnover in in Postmenopausal Women With Osteopen. K Lampropoulou-Adamidou, E Karlafti, C Argyrou, K Makris, G Trovas, et al. Journal of Clinical Densitometry 25 (3), 357-372. 2022
6. Do we need the replacement of YSI 2300? A view from the clinical laboratory. L Spanou, K Makris. Journal of Diabetes Science and Technology 16 (3), 756-759 1 2022
7. Teriparatide Treatment in Patients with Pregnancy-and Lactation-Associated Osteoporosis. K Lampropoulou-Adamidou, G Trovas, IK Triantafyllopoulos, et al. Calcified Tissue International 109 (5), 554-562 3 2021
8. Saliva cortisol levels and physiological parameter fluctuations in mild traumatic brain injury patients compared to controls. E Daneva, K Makris, A Korompeli, O Muurlink, I Kaklamanos, G Fildissis, et al. International Journal of Neuroscience, 1-9 2021
9. Recommendations on the measurement and the clinical use of vitamin D metabolites and vitamin D binding protein–A position paper from the IFCC Committee on bone metabolism. K Makris, HP Bhattoa, E Cavalier, K Phinney, CT Sempos, CZ Ulmer, et al Clinica Chimica Acta 517, 171-197 24 2021
10. A multicenter study to evaluate harmonization of assays for C-terminal telopeptides of type I collagen (ß-CTX): a report from the IFCC-IOF committee for bone metabolism (C-BM). E Cavalier, R Eastell, NR Jørgensen, K Makris, S Tournis, S Vasikaran, et al. Calcified Tissue International 108 (6), 785-797 5*           2021
11. ASSOCIATION OF AKI-EVENT DEFINED BY DIFFERENT DEFINITIONS WITH IN-HOSPITAL MORTALITY. F Nateghi, K Makris, P Delanaye, H Pottel. Nephrology Dialysis Transplantation 36 (Supplement_1), gfab082. 0018                 2021
12. Standardization process of continuous glucose monitoring: traceability and performance. G Freckmann, JH Nichols, R Hinzmann, DC Klonoff, Y Ju, P Diem, et al Clinica Chimica Acta 515, 5-12 23 2021
13. Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood. HP Bhattoa, E Cavalier, R Eastell, AC Heijboer, NR Jørgensen, K Makris, et al. Clinica Chimica Acta 515, 16-20 21 2021
14. The path to the standardization of PTH: Is this a realistic possibility? a position paper of the IFCC C-BM. E Cavalier, S Vasikaran, HP Bhattoa, AC Heijboer, K Makris, CZ Ulmer. Clinica Chimica Acta 515, 44-51 8 2021
15. Analytical performance specifications for 25-hydroxyvitamin D examinations. E Cavalier, CG Fraser, HP Bhattoa, AC Heijboer, K Makris, CZ Ulmer et al. Nutrients 13 (2), 431 7 2021
16. ASSOCIATION OF AKI-EVENT DEFINED BY DIFFERENT DEFINITIONS WITH IN-HOSPITAL MORTALITY F Nateghi Haredasht, K Makris, P Delanaye, H Pottel. Nephrology Dialysis and Transplantation NDT https://academic. oup. com/ndt/article/36/Supplement_1/gfab082. 0018/6288834 2021
17. Does Vitamin D affects changes in volumetric bone mineral density and architecture in postmenopausal women after conservatively treated distal radius fractures? K Raptis, K Makris, G Trovas, A Galanos, C Koutserimpas et al. Journal of Musculoskeletal & Neuronal Interactions 21 (1), 93 2021
18. EFFECT OF CALCIUM AND VITAMIN D SUPPLEMENTATION WITH AND WITHOUT COLLAGEN PEPTIDES ON BONE MINERAL DENSITY AND BONE TURNOVER IN POSTMENOPAUSAL WOMEN WITH OSTEOPENIA. G Trovas, K Lampropoulou-Adamidou, E Karlafti, C Argyrou, S Tournis, et al OSTEOPOROSIS INTERNATIONAL 31 (SUPPL 1), S193-S194 2020
19. Cardiovascular Risk in Patients with Primary Hyperparathyroidism. S Tournis, K Makris, E Cavalier, G Trovas. Current Pharmaceutical Design 26 (43), 5628-5636 8 2020
20. Identification of patients at high risk for postsurgical hypoparathyroidism K Kakava, S Tournis, K Makris, G Papadakis, E Kassi, I Dontas, et al. In vivo 34 (5), 2973-2980 5 2020
21. The measurement of vitamin D metabolites: part I—metabolism of vitamin D and the measurement of 25-hydroxyvitamin D. K Makris, C Sempos, E Cavalier Hormones 19 (2), 81-96 32 2020
22. The measurement of vitamin D metabolites part II—the measurement of the various vitamin D metabolites. K Makris, C Sempos, E Cavalier. Hormones 19 (2), 97-107 8 2020
23. Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke J Montaner, L Ramiro, A Simats, S Tiedt, K Makris, GC Jickling, S Debette, et al Nature Reviews Neurology 16 (5), 247-264 99 2020
24. Harmonization of commercial assays for PINP; the way forward SD Vasikaran, HP Bhattoa, R Eastell, AC Heijboer, NR Jørgensen, … Osteoporosis International 31 (3), 409-412 14 2020
25. Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia C Argyrou, E Karlafti, K Lampropoulou-Adamidou, S Tournis, K Makris, et al Journal of musculoskeletal & neuronal interactions 20 (1), 12 10 2020
26. Dietary patterns of Greek adults and their associations with serum vitamin D levels and heel quantitative ultrasound parameters for bone health E Grigoriou, G Trovas, N Papaioannou, I Dontas, K Makris, et al. Nutrients 12 (1), 123 6 2020
27. Relationship Between Leptin Levels (in Pregnant Women and Placenta) and Glucose Metabolism and other Metabolic Parametres in Full Term Pregnant Women. K Hatziveis, K Makris, K Tsopelas, G Tzifa, A Labropoulou, C Tzamourani, et al. Nosileftiki 58 (4) 2019
28. A multicenter study to evaluate harmonization of assays for N-terminal propeptide of type I procollagen (PINP): a report from the IFCC-IOF Joint Committee for Bone Metabolism E Cavalier, R Eastell, NR Jørgensen, K Makris, S Tournis, S Vasikaran, et al. Clinical Chemistry and Laboratory Medicine (CCLM) 57 (10), 1546-1555 18 2019
29. The impact of different creatinine criteria on the prevalence of the acute kidney injury in a population of hospitalized patients L Vranken, L Schoneveld, B Lambermont, E Cavalier, K Makris, Clinica Chimica Acta 493, S486 2019
30. Serum 25-hydroxyvitamin D status, quantitative ultrasound parameters, and their determinants in Greek population. EV Grigoriou, G Trovas, N Papaioannou, P Makras, P Kokkoris, I Dontas, et al. Archives of osteoporosis 13 (1), 1-9 18 2018
31. Is the profession of laboratory medicine uniform across the North Mediterranean countries? K Makris EJIFCC 29 (3), 180 2 2018
32. EurA1c: The European HbA1c trial to investigate the performance of HbA1c assays in 2166 laboratories across 17 countries and 24 manufacturers by use of the IFCC model for et al. Clinical Chemistry 64 (8), 1183-1192 44 2018
33. Blood biomarkers in ischemic stroke: potential role and challenges in clinical practice and research. K Makris, A Haliassos, M Chondrogianni, G Tsivgoulis Critical reviews in clinical laboratory sciences 55 (5), 294-328 91 2018
34. TERIPARATIDE TREATMENT IN EIGHT PATIENTS WITH PREGNANCY AND LACTATION-ASSOCIATED OSTEOPOROSIS K Lampropoulou-Adamidou, G Trovas, I Triantafyllopoulos et al. OSTEOPOROSIS INTERNATIONAL 29, S449-S449 2018
35. Changes of circulating microRNAs in response to treatment with teriparatide or denosumab in postmenopausal osteoporosis AD Anastasilakis, P Makras, M Pikilidou, S Tournis, K Makris, I Bisbinas, et al. The Journal of Clinical Endocrinology & Metabolism 103 (3), 1206-1213 48 2018
36. Hypophosphatemia, Severe Bone Pain, Gait Disturbance, and Fatigue Fractures After Iron Substitution in Inflammatory Bowel Disease: A Case Report. S Tournis, S Michopoulos, K Makris, E Terpos Journal of Bone and Mineral Research. 7 2018
37. Bone turnover markers. E Cavalier, R Eastell, NR Jørgensen, K Makris, S Vasikaran, HA Morris. Academic Press 4 2018
38. The role of the clinical laboratory in the detection and monitoring of acute kidney injury. K Makris. J Lab Precis Med 3, 69 8 2018
39. Physical activity may be a potent regulator of bone turnover biomarkers in healthy girls during preadolescence A Kambas, D Leontsini, A Avloniti, A Chatzinikolaou, T Stampoulis, … Journal of bone and mineral metabolism 35 (6), 598-607 15 2017
40. Bone quality assessment as measured by trabecular bone score in patients with end-stage renal disease on dialysis MP Yavropoulou, V Vaios, M Pikilidou, I Chryssogonidis, M Sachinidou, … Journal of Clinical Densitometry 20 (4), 490-497 30 2017
41. Plasma glial fibrillary acidic protein in the differential diagnosis of intracerebral haemorrhage AH Katsanos, K Makris, D Stefani, K Koniari, E Gialouri, M Lelekis, … Stroke 48 (9), 2586-2588 58 2017
42. Physical activity is negatively correlated with circulating sclerostin in 6–12 year-old children T Stampoulis, D Leontsini, A Avloniti, D Draganidis, K Papanikolaou, et al. Bone Abstracts 6 2017
43. Systematic vitamin D supplementation and monitoring: improving outcomes in heart failure? D Gruson, AC Pouleur, K Makris, C Chrysohoou European Journal of Heart Failure 19 (5), 686-687 4. 2017
44. Circulating Sclerostin responses to acute weight and non-weight bearing sport activity in pre-adolescent males AZ Jamurtas, D Leontsini, A Avloniti, D Vlachopoulos, T Stampoulis, … Ovid Technologies (Wolters Kluwer Health) 2017
45. Clinical usefulness of bone turnover marker concentrations in osteoporosis HA Morris, R Eastell, NR Jorgensen, E Cavalier, S Vasikaran, SAP Chubb, et al. Clinica chimica acta 467, 34-41 111 2017
46. Effect of calcitriol on FGF23 level in healthy adults and its dependence on phosphate level E Georgiadou, H Marketou, G Trovas, I Dontas, N Papaioannou, K Makris, … in vivo 31 (1), 145-150 16 2017
47. Acute kidney injury: diagnostic approaches and controversies K Makris, L Spanou The Clinical Biochemist Reviews 37 (4), 153 80 2016
48. Changes of serum sclerostin and Dickkopf-1 levels during the menstrual cycle. A pilot study CG Liakou, G Mastorakos, K Makris, IG Fatouros, A Avloniti, H Marketos, … Endocrine 54 (2), 543-551 12 2016
49. Neutrophil gelatinase–associated lipocalin as an early marker of contrast‐induced nephropathy after elective invasive cardiac procedures N Kafkas, C Liakos, F Zoubouloglou, O Dagadaki, S Dragasis, K Makris Clinical Cardiology 39 (8), 464-470 28 2016
50. Acute kidney injury: definition, pathophysiology and clinical phenotypes K Makris, L Spanou. The clinical biochemist reviews 37 (2), 85 546 2016
51. ASSESSMENT OF BONE MINERAL DENSITY AND TRABECULAR BONE SCORE IN CHRONIC DIALYSIS PATIENTS M Yavropoulou, V Vaios, I Chryssogonidis, M Pikilidou, M Sachinidou, et al. OSTEOPOROSIS INTERNATIONAL 27, S450-S450 2016
52. Evaluation of bone metabolism in critically ill patients using CTx and PINP A Gavala, K Makris, A Korompeli, P Myrianthefs. BioMed research international 2016 13 2016
53. Prognostic significance of serum albumin level changes in acute ischemic stroke: the role of biological and analytical variation K Makris, K Koniari, L Spanou, E Gialouri, E Evodia, M Lelekis. Clinical Chemistry and Laboratory Medicine (CCLM) 54 (1), 143-150 12 2016
54. Evaluation of a particle enhanced turbidimetric assay for the measurement of neutrophil gelatinase-associated lipocalin in plasma and urine on Architect-8000: Analytical et al. K Makris, D Stefani, E Makri, I Panagou, M Lagiou, A Sarli, M Lelekis, et al. Clinical Biochemistry 48 (18), 1291-1297 26 2015
55. B-type natriuretic peptide vs. cardiac risk scores for prediction of outcome following major orthopedic surgery S Katsanos, D Babalis, N Kafkas, A Mavrogenis, D Leong, J Parissis, … Journal of Cardiovascular Medicine 16 (6), 465-471 13 2015
56. Volumetric bone mineral density and bone geometry assessed by peripheral quantitative computed tomography in women with differentiated thyroid cancer under TSH suppression. S Tournis, JD Antoniou, CG Liakou, J Christodoulou, E Papakitsou, … Clinical endocrinology 82 (2), 197-204 52 2015
57. Urinary cystatin C as an early biomarker of acute kidney injury after open and endovascular abdominal aortic aneurysm repair KM Pirgakis, K Makris, I Dalainas, AM Lazaris, CK Maltezos, CD Liapis Annals of Vascular Surgery 28 (7), 1649-1658 31 2014
58. EVALUATION OF BONE. METABOLISM USING CTX AND PINP MARKERS IN CRITICALLY ILL PATIENTS. A Gavala, K Makris, A Korompeli, I Pavlopoulou, E Konstantinou, … INTENSIVE CARE MEDICINE 40, S149-S149 2014
59. Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of contrast-induced nephropathy in patients undergoing elective cardiac catheterization N Kafkas, K Makris, C Liakos, S Georgopoulos, A Mouzarou, D Babalis EUROPEAN HEART JOURNAL 35, 128-129 2014
60. Effect of parathyroidectomy versus risedronate on volumetric bone mineral density and bone geometry at the tibia in postmenopausal women with primary hyperparathyroidism S Tournis, E Fakidari, I Dontas, C Liakou, J Antoniou, A Galanos, et al. Journal of bone and mineral metabolism 32 (2), 151-158 31 2014
61. Drops Supplementation for Treating Vitamin D Deficiency in Healthy Children and Adolescents: The Important Role of Sun Exposure. A Papadopoulou, K Makris, M Tsohantari, M Paulakou, S Lambidi, et al. International Journal of Pediatrics 2 (1), 11 2014
62. The effect of glucose loading on adiponectin levels in diabetes mellitus type 2. Implications for Endothelial Dysfunction K Koniari, D Tousoulis, C Antoniades, A Nikolopoulou, E Voltyrakis Journal of Disease Markers 1 (2), 6 1 2014
63. Hip fracture leading to the diagnosis of autosomal dominant hypophosphatemic rickets. A case report S Tournis, T Koromila, N Chatzistamatas, M Droggaris, C Zafeiris, et al. J Musculoskelet Neuronal Interact 13 (3), 391-394 6 2013
64. Measurement of cystatin C in human urine by particle-enhanced turbidimetric immunoassay on an automated biochemistry analyser K Makris, E Nikolaki, K Nanopoulos, KM Pirgakis, CK Maltezos Clinical Biochemistry 46 (12), 1128-1130 11 2013
65. Late onset autosomal dominant hypophosphatemic rickets; confirmation of the diagnosis with genomic analysis S Tournis, I Stathopoulos, K Lampropoulou-Adamidou, T Koromila, et al. Bone Abstracts 1 2013
66. Serum levels of gelatinase associated lipocalin as indicator of the inflammatory status in coronary artery disease N Kafkas, C Demponeras, F Zoubouloglou, L Spanou, D Babalis, et al. International journal of inflammation 2012 55 2012
67. Neurophil gelatinase-associated lipocalin as a new biomarker in laboratory medicine K Makris, D Rizos, N Kafkas, A Haliassos Clinical Chemistry and Laboratory Medicine (CCLM) 50 (9), 1519-1532 97 2012
68. Neutrophil gelatinase-associated lipocalin in acute kidney injury K Makris, N Kafkas Advances in clinical chemistry 58, 143 38 2012
69. The Greek way to the register: the establishment and operation of the register for clinical chemists-clinical biochemists in Greece D Rizos, P Karababa, C Nikolou, A Sarandakou, O Panagiotakis, et al. Clinical Chemistry and Laboratory Medicine (CCLM) 49 (12), 1975-1978 3 2011
70. Is there a relationship between mean blood glucose and glycated hemoglobin? K Makris, L Spanou Journal of diabetes science and technology 5 (6), 1572-1583 107 2011
71. Brain natriuretic peptide: a marker of cardiac dysfunction with ventricular or dual-chamber pacing N Kafkas, S Patsilinakos, K Makris, G Chlapoutakis, A Christou, … Acta Cardiologica 66 (5), 589-594 13 2011
72. THE OUTCOME OF NGAL-POSITIVE SUBCIANICAL ACUTE KIDNEY INJURY: A MULTICENTER POOLED ANALYSIS OF PROSPECTIVE STUDIES M Haase, A Haase-Fielitz, P Devarajan, R Bellomo, DN Cruz, G Wagener, et al. INTENSIVE CARE MEDICINE 37, S237-S237 2011
73. Ischemia modified albumin (IMA) as a potent biomarker for the early identification of acute stroke. A Koniari, E Gialouri, M Nikolaou, O Glezakou, I Drakopoulos, K Makris EUROPEAN HEART JOURNAL 32, 559-559 2011
74. The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies M Haase, P Devarajan, A Haase-Fielitz, R Bellomo, DN Cruz, G Wagener, … Journal of the American College of Cardiology 57 (17), 1752-1761 764 2011
75. The organisation of an educational program for specialists in clinical chemistry by the Greek Society of Clinical Chemistry-Clinical Biochemistry D Rizos, P Karababa, A Sarandakou, O Panagiotakis, A Haliassos, et al. Biochemia Medica 21 (1), 30-37 3 2011
76. THE IMPACT OF VARIATION IN SERUM CREATININE DETERMINATIONS ON GFR ESTIMATION (eGFR)—ANALYSIS OF DATA FROM THE GREEK EXTERNAL QUALITY ASSESSMENT SCHEME A Haliassos, K Makris, S Potamitis, I Drakopoulos, D Rizos Clinical Chemistry and Laboratory Medicine 48 (9) 2010
77. Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis M Haase, R Bellomo, P Devarajan, P Schlattmann, A Haase-Fielitz, et al. American journal of kidney diseases 54 (6), 1012-1024 1276 2009
78. Relationship between mean blood glucose values and HbA (1c) in diabetic pregnant women G Papageorgiou, K Makris, K Economou, A Athanasiadou, M Alevizaki, … DIABETOLOGIA 52, S462-S462 2009
79. Microalbuminuria is an early marker of SIRS in critically ill patients K Makris, E Tsigou, E Evodia, F Zoubouloglou, I Drakopoulos, … INTENSIVE CARE MEDICINE 35, 242-242 1 2009
80. SERUM CYSTATIN C AS AN EARLY MARKER OF ACUTE KIDNEY INJURY IN CRITICALLY ILL PATIENTS. PRELIMINARY DATA. E Evodia, E Tsigou, K Makris, F Zoumpouloglou, I Drakopoulos, et al. INTENSIVE CARE MEDICINE 35, 222-222 2009
81. Usefulness of urinary neutrophil gelatinase associated lipocalin to urinary creatinine ratio for monitoring of n-acetyl cysteine efficacy in contrast induced nephropathy. C Demponeras, N Kafkas, K Makris, A Nikolaou, K Triantafillou, et al. EUROPEAN HEART JOURNAL 30, 527-528 2009
82. Ratio of Urinary Neutrophil Gelatinase Associated Lipocalin to urinary creatinine as predictor of contrast induced nephropathy after coronary angiography N Kafkas, C Demponeras, K Makris, A Nikolaou, K Triantafillou, et al. EUROPEAN HEART JOURNAL 30, 538-5382009
83. USE OF MYELOPEROXIDASE LEVELS FOR THE EARLY IDENTIFICATION OF CORONARY ARTERY DISEASE IN CHEST-PAIN PATIENTS AT THE EMERGENCY DEPARTMENT K Makris, C Demponeras, P Petraki, F Zoubouloglou, S Potamitis, et al. CLINICAL CHEMISTRY 55 (6), A61-A61 2009
84. The role of urinary NGAL to urinary creatinine ratio in the early detection of contrast agent induced acute kidney injury after coronary artery angiography K Makris, C Demponeras, F Zoubouloglou, S Potamitis, N Kafkas, et al. CLINICAL CHEMISTRY 55 (6), A161-A161 5 2009
85. LEVELS OF VON WILLEBRAND FACTOR ON ADMISSION CAN DISCRIMINATE PATIENTS WITH ACUTE CORONARY SYNDROME FROM A GROUP OF PATIENTS WITH CHEST PAIN. T Assimakopoulou, N Tragomalos, M Stamouli, P Petraki, K Makris, et al. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 94, 664-665 2009
86. Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients. K Makris, N Markou, E Evodia, E Dimopoulou, I Drakopoulos, K Ntetsika, .et. al. Clinical chemistry and laboratory medicine 47 (1), 79-82 286 2009
87. Deoxyfructosyl haemoglobin (beta) values in normal and gestational diabetic pregnancy. E Anastasiou, K Economou, G Papageorgiou, M Alevizaki, L Spanou, et al. DIABETOLOGIA 51, S465-S465 2008
88. Early markers of acute kidney injury in ICU multitrauma patients. Preliminary report. K Makris, I Drakopoulos, E Evodia, K Ntetsika, N Markou, E Dimopoulou, et al. CLINICAL CHEMISTRY 54 (6), A177-A177 2008
89. Changes of ischemia modified albumin (IMA) in patients with acute stroke. K Makris, I Drakopoutos, K Koniari, E Gialouri, O Glezakou, et al. CLINICAL CHEMISTRY 54 (6), A85-A85. 2008
90. Evaluation of Pregnancy Associated Plasma Protein A (PAPP-A) and free beta human chorionic gonadotrophin (free beta-hCG) on Siemens Immulite in comparison with Brahms Kryptor et al. A Haliassos, S Michaloliakou, K Makris, P Vlachakis, D Rizos CLINICAL CHEMISTRY 54 (6), A111-A111. 2008
91. Effectiveness of different anti-hypertensive drugs in lowering ventricular premature beats G Floros, S Katsanos, K Makris, N Kafkas, G Hlapotttakis, D Sideris JOURNAL OF HYPERTENSION 26, S505-S505 1 2008
92. Decreased apolipoprotein A1 levels correlate with sepsis and adverse outcome among ICU patients. E Pavlou, K Makris, A Palaiologou, B Kaldis, G Vrioni, E Economou, et al. Critical Care 12 (2), 1-1. 2008
93. Biochemical markers of the iron metabolism and their relationship with the inflammatory status in multiple trauma patients. E Pavlou, K Makris, A Palaiologou, O Tsimpoukidou, P Sarafidou, et al. Critical Care 12 (2), 1-1. 2008
94. Relationship between mean blood glucose and glycated haemoglobin in type 2 diabetic patients. K Makris, L Spanou, A Rambaouni‐Antoneli, K Koniari, I Drakopoulos, et al. Diabetic Medicine 25 (2), 174-178 38 2008
95. Performance evaluation of Bayer Asencsia (R)-Contour (R) portable blood glucose monitoring system. A Haliassos, I Drakopoulos, E Feskou, A Rambaouni-Antonelli, L Spanou, et al. CLINICAL CHEMISTRY 53 (6), A217-A217 2007
96. Correlation of mean blood glucose (MBG) with glycated haemoglobin (HbA1c) in type2-diabetic patients. K Makris, L Spanou, A Rambaouni-Antonelli, I Drakopoulos, M Vlahou, et al. CLINICAL CHEMISTRY 53 (6), A189-A189 2007
97. Measurement of glycated hemoglobin (HbA1c) with an automated POCT instrument in comparison with HPLC and automated immunochemistry method: evaluation of the influence of et al. A Haliassos, I Drakopoulos, D Katritsis, N Chiotinis, S Korovesis, K Makris Clinical Chemistry and Laboratory Medicine (CCLM) 44 (2), 223-227 28 2006
98. Correlation between three Nt-proBNP and BNP automated measurement methods K Makris, I Drakopoulos, A Haliassos, H Vidali, D Katritsis, D Leftheriotis, et al. CLINICA CHIMICA ACTA 355, S111-S111 2005
99. Correlation of mean blood glucose (MBG) values derived from glycated haemoglobin (HBA (1c)) with fasting glucose levels. A Haliassos, I Drakopoulos, D Katritsis, H Vidali, A Chiotinis, K Makris. CLINICA CHIMICA ACTA 355, S345-S345. 2005
100. Definition of reference ranges for” mean blood glucose (MBG)” as reflected from Glycated Hemoglobin (HbA (1c)) measurements. A Haliassos, N Chiotinis, K Makris, D Katritsis, I Drakopoulos. CLINICAL CHEMISTRY 51, A31-A31 2005
101. Frequency and characteristics of post‐transfusion hepatitis in Greece with emphasis on hepatitis C: comparing second‐and third‐generation assays. K Makris, V Kouvelis, I Drakopoulos, E Oikonomou, A Maniatis. Transfusion Medicine 5 (3), 213-224 13 1995

ΔΗΜΟΣΙΕΥΣΕΙΣ ΣΕ ΔΙΕΘΝΗ ΕΠΙΣΤΗΜΟΝΙΚΑ ΠΕΡΙΟΔΙΚΑ 2023 – 2024

1. Vitamin D: Analytical Advances, Clinical Impact, and Ongoing Debates on Health Perspectives. Cavalier E, Makris K, Heijboer AC, Herrmann M, Souberbielle JC. Clin Chem. 2024 May 7:hvae056. doi: 10.1093/clinchem/hvae056. Online ahead of print.PMID: 38712647
2. Improving the Bias of Comparator Methods in Analytical Performance Assessments Through Recalibration. Pleus S, Eichenlaub M, Gerber T, Eriksson Boija E,Makris K, Haug C, Freckmann G. J Diabetes Sci Technol. 2024 May;18(3):686-694. doi: 10.1177/19322968221133107. Epub 2022 Oct 22.PMID: 36278402
3. Comparator Data Characteristics and Testing Procedures for the Clinical Performance Evaluation of Continuous Glucose Monitoring Systems. Eichenlaub M, Pleus S, Rothenbühler M, Bailey TS, Bally L, Brazg R, Bruttomesso D, Diem P, Eriksson Boija E, Fokkert M, Haug C, Hinzmann R, Jendle J, Klonoff DC, Mader JK, Makris K, Moser O, Nichols JH, Nørgaard K, Pemberton J, Selvin E, Spanou L, Thomas A, Tran NK, Witthauer L, Slingerland RJ, Freckmann G. Diabetes Technol Ther. 2024 Apr;26(4):263-275. doi: 10.1089/dia.2023.0465. Epub 2024 Feb 2.
4. Vitamin D and vitamin K status in postmenopausal women with normal and low bone mineral density. Zelzer S, Meinitzer A, Enko D, Markis K, Tournis S, Trifonidi I, Chronopoulos E, Spanou L, Alonso N, Keppel M, Herrmann M. Clin Chem Lab Med. 2024 Jan 1. doi: 10.1515/cclm-2023-1443. Online ahead of print. PMID: 38158723
5. Assessing the status of European laboratories in evaluating biomarkers for chronic kidney diseases (CKD) and recommendations for improvement: insights from the 2022 EFLM Task Group on CKD survey. Cavalier E, Makris K, Portakal O, Nikler A, Datta P, Zima T, Delanaye P; EFLM Task Group on CKD. Clin Chem Lab Med. 2023 Oct 2;62(2):253-261. doi: 10.1515/cclm-2023-0987. Print 2024 Jan 26.
6. Site specific differences in vBMD and geometry in postmenopausal women with primary hyperparathyroidism. Karlafti E, Dontas I, Lambrinoudaki I, Vlamis I, Lampropoulou-Adamidou K, Makris K, Trifonidi I, Galanos A, Trovas G, Chronopoulos E, Tournis S. 2024 Jan;83(1):205-213. doi: 10.1007/s12020-023-03491-8. Epub 2023 Aug 19. PMID: 37597095
7. Clinical Performance Evaluation of Continuous Glucose Monitoring Systems: A Scoping Review and Recommendations for Reporting. Freckmann G, Eichenlaub M, Waldenmaier D, Pleus S, Wehrstedt S, Haug C, Witthauer L, Jendle J, Hinzmann R, Thomas A, Eriksson Boija E, Makris K, Diem P, Tran N, Klonoff DC, Nichols JH, Slingerland RJ. J Diabetes Sci Technol. 2023 Nov;17(6):1506-1526. doi: 10.1177/19322968231190941. Epub 2023 Aug 20. PMID: 37599389
8. Analytical performance specifications for the measurement uncertainty of 24,25-dihydroxyvitamin D examinations. Cavalier E, Fraser CG, Bhattoa HP, Heijboer AC, Makris K, Vasikaran S, Huyghebaert L, Peeters S, Le Goff C, Herrmann M, Carobene A; IFCC-IOF Committee for Bone Metabolisma. Clin Chem Lab Med. 2023 Mar 31;61(9):1561-1566. doi: 10.1515/cclm-2023-0176. Print 2023 Aug 28. PMID: 36995129
9. Saliva cortisol levels and physiological parameter fluctuations in mild traumatic brain injury patients compared to controls. Daneva E, Makris K, Korompeli A, Muurlink O, Kaklamanos I, Fildissis G, Vlachos K, Myrianthefs P. Int J Neurosci. 2023 Jun;133(6):612-620. doi: 10.1080/00207454.2021.1951264. Epub 2021 Jul 20. PMID: 34228947
10. Sarcopenia in Rheumatoid arthritis. A narrative review. Moschou D, Krikelis M, Georgakopoulos C, Mole E, Chronopoulos E, Tournis S, Mavragani C, Makris K, Dontas I, Gazi S. J Frailty Sarcopenia Falls. 2023 Mar 1;8(1):44-52. doi: 10.22540/JFSF-08-044. eCollection 2023 Mar. PMID: 36873824
11. Alkaline Phosphatases: Biochemistry, Functions, and Measurement. Makris K, Mousa C, Cavalier E. Calcif Tissue Int. 2023 Feb;112(2):233-242. doi: 10.1007/s00223-022-01048-x. Epub 2022 Dec 26. PMID: 36571614